Decoding Human Hematopoietic Stem Cell Self-Renewal
نویسندگان
چکیده
Abstract Purpose of Review Hematopoietic stem cells (HSCs) maintain blood and immune cell homeostasis by balancing quiescence, self-renewal, differentiation. HSCs can be used in lifesaving transplantation treatments to create a healthy hematopoietic system patients suffering from malignant or inherited diseases. However, lack matching bone marrow donors, the low quantity single cord graft, are limitations for successful transplantation. The enormous regenerative potential has raised hope that HSC self-renewal could recapitulated culture achieve robust expansion therapeutic use. Yet, when cultured ex vivo their function becomes compromised, limiting expansion. Recent Findings After decades efforts expand human resulted minimal increase transplantable units, recent studies have helped define conditions functional HSCs. These provided new insights into how stemness controlled nucleus transcriptional, posttranscriptional epigenetic regulators, improving microenvironment using 3D scaffolds, niche cells, signaling molecules mimic specific aspects niche. also highlighted importance mitigating induced cellular stress mitochondrial, endoplasmic reticulum, lysosomal functions. discoveries better markers engraftment ability may vivo. Summary Uncovering mechanisms control process help improve clinical purposes.
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ژورنال
عنوان ژورنال: Current stem cell reports
سال: 2022
ISSN: ['2198-7866']
DOI: https://doi.org/10.1007/s40778-022-00209-w